Adenylate Kinase 5 antibody (N-Term)

Catalog No. ABIN392733

This anti-Adenylate Kinase 5 antibody is a Rabbit Polyclonal antibody detecting Adenylate Kinase 5 in WB and IHC (p). Suitable for Human and Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for Adenylate Kinase 5 antibody (N-Term) (ABIN392733)

Target: Adenylate Kinase 5 (AK5)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Adenylate Kinase 5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3883

Product Details anti-Adenylate Kinase 5 Antibody

Binding Specificity: AA 404-433, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This AK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-433 amino acids from the N-terminal region of human AK5.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Adenylate Kinase 5 antibody (ABIN392733)

Saito, Kitamura, Hijikata, Tomizawa-Murasawa, Tanaka, Takagi, Uchida, Suzuki, Sone, Najima, Ozawa, Wake, Taniguchi, Shultz, Ohara, Ishikawa: "Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells." in: Science translational medicine, Vol. 2, Issue 17, pp. 17ra9, (2010) (PubMed).

Target Details for Adenylate Kinase 5

Target: Adenylate Kinase 5 (AK5)

Alternative Name: AK5

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Molecular Weight: 63333

Gene ID: 26289

NCBI Accession: NP_036225, NP_777283

UniProt: Q9Y6K8

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process